Case Reports
Vol. 58 No. 3 (2006)
https://doi.org/10.4081/reumatismo.2006.230

Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer

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Authors

C.U. Manzini
office@pagepress.org
, Italy.
L. Bernardini
, Italy.
N. Elkhaldi
, Italy.
M.T. Mascia
, Italy.
C. Ferri
, Italy.
The treatment of bladder cancer with Bacillus of Calmette-Guerin (BCG) immunotherapy can induce the appearance of a reactive disorder. The Authors describe a 55-year-old male patient with bladder cancer treated with endovesical instillation of BCG immunotherapy, followed after the fifth application by asymmetric oligoarthritis and dactilitis. The observed positivity of both HLA-B27 and HLA-B51 antigens reinforces the hypothesis of a reactive form, possibly through "molecular mimicry" mechanism. The discontinuation of BCG instillation along which a therapeutic attempt with NSAD failed to improve the rheumatic manifestation, which completely remitted after a four-month course of oral steroids. No relapses of joint and tendon involvement was observed during the following five-month period. The clinico- pathogenetic implications suggested by this case are discussed.

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1.
Dactilitis and oligoarthritis after BCG immunotherapy in a patient affected by bladder cancer. Reumatismo [Internet]. 2006 Sep. 30 [cited 2026 Sep. 9];58(3):230-2. Available from: https://www.reumatismo.org/reuma/article/view/reumatismo.2006.230

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