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Demyelinating syndrome in SLE: review of different disease subtypes and report of a case series

E. Chessa, M. Piga, A. Floris, A. Mathieu, A. Cauli
  • M. Piga
    Rheumatology Unit, University Clinic AOU of Cagliari, Italy
  • A. Floris
    Rheumatology Unit, University Clinic AOU of Cagliari, Italy
  • A. Mathieu
    Rheumatology Unit, University Clinic AOU of Cagliari, Italy
  • A. Cauli
    Rheumatology Unit, University Clinic AOU of Cagliari, Italy

Abstract

Demyelinating syndrome (DS) is a rare manifestation of systemic lupus erythematosus (SLE) (1%) with high clinical heterogeneity and potentially severe prognosis. It can represent a diagnostic and therapeutic challenge for clinicians. A recent study described 5 different patterns of demyelinating disease presentation, characterised by specific clinical, laboratory and brain and spine magnetic resonance imaging abnormalities: 1) neuromyelitis optica; 2) neuromyelitis optica spectrum disorders; 3) DS prevalently involving the brain; 4) DS prevalently involving the brainstem; 5) clinically isolated syndrome. In this review we briefly discuss typical characteristics of each DS presentation in SLE and we describe 5 illustrative clinical cases, one for each subset of DS, considering both diagnostic and therapeutic options.

Keywords

Systemic lupus erythematosus; Demyelinating syndrome; Neuropsychiatric lupus; Magnetic resonance.

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Submitted: 2017-05-05 19:13:06
Published: 2017-12-21 16:24:05
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Copyright (c) 2017 E. Chessa, M. Piga, A. Floris, A. Mathieu, A. Cauli

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